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PainJournal.net Clinical Journal of Pain for Healthcare Professionals and Patients
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Treatment of 9 Patients with Chronic Pancreatitis Pain using Interpleural Catheters over a 5 Year Period
Method 9 Patients were treated for chronic pancreatitis pain with intermittent insertions of interpleural catheters over a 5 year period. At the onset of severe pain the patients were admitted to hospital for 72 hours and 20 ml.of Bupivicaine 0.5% with epinephrine was instilled through the catheter three times daily. These patients were followed both in the Northside General Hospital Chronic Non-Malignant Pain Clinic and by telephone interview carried out by a clinic secretary to assess the long term results of this treatment. The paper will demonstrate the techniques employed, review the potential complications, discuss the mechanism of action and show the short and long term results with this intervention. INTERPLEURAL CATHETER INSERTION FOR CHRONIC PANCREATITIS PAIN DEMOGRAPHICS - 9 PATIENTS
Duration of Pain: A. > 6 months 2 B. 6 months - 1 yr. 1 C. 1 - 2 yrs. 1 D. < 2 yrs. 5
MECHANISMS OF ACTION OF INTERPLEURAL ANESTHESIA 1. The diffusion of the local anesthetic from the pleural space through the parietal pleural and the inner most intercostal muscles, causing multiple intercostal unilateral nerve blocks. 2. A unilateral block of thoracic sympathetic chain and the splanchnic nerve is produced by drug traversing the parietal pleural paraspinally. 3. Diffusion of the anesthetic to the ipsilateral brachial plexus.
INDICATIONS FOR THE USE OF INTERPLEURAL ANAESTHESIA FOR CHRONIC PAIN MANAGEMENT. Chronic Pancreatitis Pain -Postherpetic neuralgia -Reflex sympathetic dystrophies of the arm/face -Frozen shoulders -Upper abdominal cancer pain -Chest wall and thoracic visceral pain -Pain of pancreatic cancer other abdominal cancer OTHER INDICATIONS Post operative Analgesia -Cholecystectomy -Breast Surgery -Renal Surgery -Other subcostal incisions -Multiple rib fractures -Thoracotomy Surgical Anaesthesia -Breast biopsy & lumpectomy -Percutaneous hepatic & renal drainage procedures -Lithotripsy COMPLICATIONS OF INTERPLEURAL ANAESTHESIA
- Pneumothorax with a reported incidence of less than 5% is the most common complication. - Laceration of the intercostal neurovascular structures. - Local anaesthetic toxicity. - Empyema - Formation of a broncho pleural fistula. OTHER TREATMENTS FOR CHRONIC PANCREATITIS PAIN GENERAL MEASURES -Diet/Activity-Behaviour modification -Narcotic analgesics -Non narcotic analgesics -Tens application SPECIFIC MEASURES -Celiac plexus blockade with local anesthetic and steroid -Celiac Plexus Block with ablative agent such as phenol or absolute alcohol. -continuous lumbar epidural local anesthetic blockade.RESULTS Pain Level on Visual Analogue Scale Patient Before Treatment After Treatment 1 7 0 2 10 5 3 10 0 4 8.5 4 5 10 4.5 6 6.5 2.5 7 7.5 3.5 8 10 4 9 10 5 AVERAGE PAIN SCORE: Before Treatment 8.8 After Treatment 3.2
RESULTS Average Time between Treatments Patient Total Number Time Between Of Treatments Treatments
1 1 7mths. 2 1 9mths. 3 4 5mths. 4 1 52mths. 5 5 10.5mths. 6 3 2.5mths. 7 1 7mths. 8 3 2.5mths. 9 29 2mths.
AVERAGE TIME BETWEEN TREATMENTS: 10.5 MONTHS
PRESENT STATUS OF PATIENTS
PATIENT COMMENTS "Return of appetite and able to enjoy activities of daily living." "Helps to cope with any increasing pain rather then taking medication." "Recommend this treatment to anyone who experiences pain associated with chronic pancreatitis." DISCUSSION The 9 patients were instructed to phone in when the pancreatitis pain returned so they could be admitted for another treatment. There was some variation in how long they would wait before requesting admission, but in general the time between treatments reflects the duration of pain relief from one interpleural catheter insertion. The average time was 10.5 months, but the time varied from 2 weeks to 52 months. The drop in pain score was from the time of admission to discharge. Some of the patients are on opiate medication and their requirements would drop after treatment. There was one occurrence of pneumothorax during the study. After the pneumothorax was treated, the interpleural catheter was reinserted. Rapid changes in weight are common. One patient gained 20 Kg. in one month, then lost most of it the following month. Most patients reported relief from nausea when the catheter was in place and improvement in appetite. Two patients who appeared on the verge of starvation prior to treatment returned to a normal weight for their height and age within six months after commencement of treatment. Patients commonly complain of shoulder tip pain the first night in hospital. No instillations of bupivicaine were made between 1800 hrs. and 0800 hrs. the next morning. Additional opiate analgesia was made available during those hours.
SUMMARY Nine patients were treated for chronic pancreatitis pain with repeated insertion of left interpleural catheters when needed for their pain. All nine reported a decrease in pain level after a treatment, with an average decrease from 8.8 to 3.2 on the visual analogue scale. The average time between necessary treatments ranged from 2 months to 52 months with an average of 10.5 months. Three of the nine patients had previously been treated with coeliac plexus blocks. All felt that the pain relief from the interpleural catheter was superior. Since the beginning of 2002 four patients with cancer(3 ca. pancreas, 1 stomach) have received this treatment in our clinic. All reported pain relief while the catheter was in place, and two have reported prolonged pain relief. One, who had been in intense pain for 17 months has been pain free for 8 weeks. The use of interpleural catheters for pancreatitis pain has been reported as early as 1988 but has not come into wide use.(4) The purpose of this paper is to raise awareness of this technique which we have found to be so beneficial for our patients.
Insertion of Interpleural Catheter Step One: Prepare the patient.
The patient lies with the right side down with a small pillow under the lumbar area.
The catheter is placed in the mid-axillary line just below the edge of the lung. Chest is auscultated and the interspace where the breath sounds start to disappear is marked. This is usually the T10-11 interspace.
Insertion of Interpleural Catheter Step Two: Prepare necessary materials.
In preparation of the inter pleural catheter an epidural mini-pack is opened and the tip of the catheter is cut to remove the side holes on the catheter. If the side holes are left in place they can cause an inadvertent interstitial injection of local anaesthetic into the chest wall rather than into the inter pleural space. Insertion of Interpleural Catheter Step Three: Insert Tuohy needle and find loss of resistance.
After infiltrating the skin with local anaesthetic, the skin over the insertion site is retracted caudad. An ordinary 18 gauge needle is used to make a hole in the skin and the Tuohy needle is inserted to contact the rib immediately below the insertion point. Then a glass syringe filled with 5ml of .5% Marcaine E is attached to the needle and the skin is allowed to return to the cephalad position and the Tuohy needle is slid over the top of the rib, the needle is advanced through the parietal pleura until a loss of resistance is found and the fluid in the syringe can be easily injected.
Insertion of Interpleural Catheter Step Four: Pass the interpleural catheter and remove the Tuohy needle.
The catheter is threaded through the Tuohy needle into the interpleural space . Once 3 or 4 centimetres of catheter have been passed through the tip of the needle the Tuohy needle is slid off the catheter. Insertion of Interpleural Catheter
Step Five: Place the injection hub on the catheter and test it.
The hub is then placed on the end of the catheter with an anti bacterial filter and the remainder of the Marcaine E in the glass syringe is injected through the bacterial filter to test the catheter. Prior to attaching the bacterial filter to the hub it should be filled with the local anaesthetic solution to avoid injecting air into the interpleural space. Insertion of Interpleural Catheter Step Seven: Inject the catheter.
The remainder of the 20ml of Marcaine E .5% is injected using a regular ten millilitre syringe through the catheter. While injecting place your index finger over the injection site to prevent the jet effect from pushing the catheter out through the insertion site. After the catheter has been placed and tested the patient is placed in a Semi-Fowlers position for about 5 minutes to allow the local anaesthetic to set in the proper position. The vital signs are checked every half hour for the first two hours and an intravenous of ringers lactate is run at a 100ml/ hour for that period of time. A chest x-ray is taken to rule out pneumothorax and the patient is returned to the ward. Over the next two days the patient is given 20ml of .5% Marcaine E through the catheter 3 times a day. It is not unusual for the patient to experience some shoulder pain and moderate discomfort during the first night and narcotic sedation should be made available. Generally speaking they are more comfortable on the second night. On the evening of the third day after the third infusion of local anaesthetic through the catheter, the catheter is removed, the skin area is washed and a band-aid is placed on the injection site. The patient can be discharged within the hour from the hospital. REFERENCES -INTERPLEURAL CATHETERS 1. Myers D, O’Leary K. and Lena M, Interpleural Catheters; Indications & Techniques in Waldman, Winnie (ed) Interventional Pain Management, Saunders, 1996. PP. 319-323. 2. Mandl F: Paravertebral Block, New York, Grune & Stratton, 1947, pp 34-37. 3. Reistad F, Stromskag K: Interpleural catheter in the management of postoperative pain. Reg Anesth 11:89-91, 1986. 4. Durrani Z, Winni A, lkuta P: Interpleural catheter analgesia for pancreatic pain, Anesth Analg 67:479-481,1988. 5. Fineman 5: Long-term post thoracotomy cancer pain management with interpleural bupivacaine. Anesth Analg 68:694-697, 1989. 6. Riegler F, Vadeboncouer T: Interpleural anesthetics in the dog: Differential somatic neural blockade. Anesthesiology 71:744-50, 1989. 7. Reistad F, Kvalheim L: Continuous intercostal blocks for post operative pain relief. Norwegian Med Assoc J 104:485-487, 1984 8. Ahlburg P, Noreng M, Nolgaard J, Edebo K: Treatment of pancreatic pain with interpleural bupivacaine : an open tiral. Acta Anesthesiol Scand 34:156-1 57, 1988. 9. Myers DP, Lema MJ, deLeon-Casasola OA, Bacon DR: Interpleural analgesia for the treatment of severe cancer pain in terminally ill patients. J. Pain Symptom Manage 8:505-510, 1993. 10. Gomez MN, Symreng T, Rossi NP, Chiang CK: Interpleural bupivacaine for intraoperative analgesia: A dangerous technique? Anesth Analg 67:578, 1988. 11. Lema MJ, Myers DP, deLeon-Casasola OA, Penetrate R: Pleural phenol therapy for treatment of chronic pain. Reg Anesth 17:166-170, 1992. 12. Stromskag KE, Reiestad F, Holmquist ELOL Interpleural administration of 0.25%, 0.37%, and 0.5% bupivacaine with epinephrine after cholecystectomy. Anesth Analg 67:430,1988. 13. Waldman SD, Allen ML, Cronen MC: Subcutaneous tunneled interpleural catheters in the relief of right upper quadrant pain of malignant origin. J. Pain Symptom Manage4:86-89, 1989. 14. Stromskag KE, Minor BG, Lindebert A: Comparison of 40 milliliters of 0.25% interpleural bupivacaine with epinephrine with 20 milliliters of 0.5% interpleural bupivacaine with epinephrine after cholecystectomy. Anesth Analg 73:397, 1991. 15. Laurito CE, Kirz LI, Vadeboncouer TR, et al: continuous infusion of interpleural bupivacaine maintains effective analgesia after cholecystectomy. Anesth Analg 72:516, 1991. 16. Van Kleef JW, Logeman A, Burm AGL, et aI: Continuous interpleural infusion of bupivacaine for postoperative analgesia after surgery with flank incisions: A double-blind comparison of 0.25% and 0.5% solutions. Anesth Ahalg 75:268, 1992. 17. Harrison P, Kent E, Lema M: Interpleural analgesia: Its use and complication in a quadriplegic patient with chronic pain. J Pain Symptom Manage 8:238-241, 1993.
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